Investigation of redox status in chronic cerebral hypoperfusion-induced neurodegeneration in rats
نویسندگان
چکیده
منابع مشابه
Investigation of redox status in chronic cerebral hypoperfusion-induced neurodegeneration in rats
Aging related reduction in cerebral blood flow (CBF) has been linked with neurodegenerative disorders including Alzheimer's disease and dementia. Experimentally, a condition of chronic cerebral hypoperfusion due to reduced CBF can be induced by permanent bilateral occlusion of common carotid arteries (2-vessel occlusion, 2VO) in rats. Since oxidative stress, leading to neuronal apoptosis and de...
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Ferulic acid (FA), a phenolic phytochemical, has been reported to exert antioxidative and neuroprotective effects. In this study, we investigated the protective effects of FA against the dysfunction of the swallowing reflex induced by ligation of bilateral common carotid arteries (2VO) in rats. In 2VO rats, topical administration of water or citric acid to the pharyngolaryngeal region evoked a ...
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ژورنال
عنوان ژورنال: Applied & Translational Genomics
سال: 2015
ISSN: 2212-0661
DOI: 10.1016/j.atg.2015.05.004